摘要
虎、狮、豹等大型猫科动物可发生犬瘟热(CD),有必要进行预防。采取某动物园未免疫的东北虎、非洲狮、猞猁血样,用中和试验检测,结果显示这些动物的犬瘟热病毒(CDV)抗体水平均小于1:5。用CD弱毒疫苗接种以上动物,幼龄动物免疫14d逐步产生抗体;成年动物体内抗体水平在两月内迅速升高,并维持在1:64以上,9～11个月后逐步下降,加强免疫后抗体又迅速升高至≥1:112。该疫苗对所有接种的动物均安全可靠。白化的孟加拉虎接种疫苗后不能产生CDV中和抗体。
Large felids, such as tigers, lions and leopards are often infected with Canine Distemper （CD）. Blood samples from pre-immune Amur tiger, African lion and lynx were collected and the antibody against CDV was measured by neutralization tests. The results showed that their CDV antibody level were all below 1：5. After inoculated with attenuated CD Vaccine, the young animals produced antibody in 14 days but the antibody levels of the adults increased rapidly within two months and maintained at titer of 1： 64, then gradually dropped after 9 to 11 months. After booster immunizing, antibody level went up rapidly to≥1：112. The vaccination was safe to the animals. Achroia Indian tiger, however, could not produce CDV neutralizing antibody after vaccination.
出处
《中国病毒学》
CSCD
2006年第4期368-370,共3页
Virologica Sinica
基金
南京建设系统科研项目(93A2005Y1059)
关键词
犬瘟热
弱毒疫苗
猫科动物
免疫
中和试验
Canine Distemper
Attenuated Vaccine
FeUds
Immune Surveillance
Neutralization Test
