青黄散治疗骨髓增生异常综合征31例临床观察

Clinical Observation on Qinghuang Powder for Treatment of 31 Cases of Myelodysplastic Syndrome

目的:系统观察中药青黄散治疗骨髓增生异常综合征(MDS)的临床疗效。方法:采用随机对照方法。61例MDS患者随机分为治疗组(青黄散组)31例和对照组(维甲酸组)30例。3个月为1个疗程。结果:青黄散组总缓解率与总有效率分别为9.7%和74.1%,维甲酸组总缓解率与总有效率分别为0与46.7%,青黄散组疗效优于维甲酸组。青黄散毒副作用主要为皮肤色素沉着、角化过度及消化道症状。结论:中药青黄散治疗MDS有确切的临床疗效,能够明显改善红系造血,提高血红蛋白含量,提高白细胞数量,明显提高患者的生活质量,且患者耐受性好,对西药无效的患者仍然有效。

Objective ：To observe clinical therapeutic effect of Qinghuang Powder on myelodysplastic syndrome（MDS）. Methods： 61 cases of MDS were randomly divided into a treatment group of 31 cases and a control group of 30 cases. The treatment group were treated with Qinghuang Powder and the control group with vitamin A acid. They were treated for 3 months. Results：The total remission rate was 9. 7% and 0 in treatment group and control group respectively;and the total effective rat was 74.1% and 46. 7% in treatment and control group,respectively. The efficacy of the treatment group was better than the control group. Main toxic-side effects in the treatment group were cutaneous pigmentation, hyperkeratosis and symptoms of the digestive tract. Conclusion： Qinghuang Powder has a definite therapeutic effect on MDS, and it can significantly improve hemopoietic function, increase hemoglobin content and count of white blood cells, and significantly improve quality of life of the patient.