灯盏细辛、黄芪注射液联合苯那普利治疗IgA肾病伴慢性肾功能不全

Fleabane injection combined with astragalin injection and benazepril in the treatment of patients with lgA nephropathy and chronic renal insufficiency

目的观察灯盏细辛注射液及黄芪注射液联合苯那普利治疗IgA肾病(IgAN)伴慢性肾功能不全的临床效果。方法将86例Lee氏分级≥Ⅲ级伴肾功能不全的IgAN患者随机分为两组:灯盏细辛、黄芪注射液联合苯那普利组(联合组)和苯那普利组,观察两组的疗效。结果①1个月后,联合组24h尿蛋白定量明显下降(P<0.01),血白蛋白(A lb)水平升高(P<0.01),疗效优于苯那普利组。②1个月后,联合组BUN有一定程度下降(P<0.01),疗效优于苯那普利组;联合组和单用苯那普利组治疗后SCr比较,联合组明显低于苯那普利组(P<0.05)。结论灯盏细辛注射液及黄芪注射液联合苯那普利治疗IgA肾病(IgAN)伴慢性肾功能不全的患者,可以减轻蛋白尿,改善和稳定肾功能,疗效优于单用苯那普利者。

Objective To observe the clinical effect of fleabane injection combined with astragalin injection and benazepril in the treatment of patients with IgA nephropathy and chronic renal ,insufficiency. Methods Eighty - six cases of IgA nephropathy patients whose renal insufficiency worse than Ⅲ degree according to Lee classification were randomly divided into 2 groups-combinational group（ fleabane injection combined＇ with astragalin injection and benazepril）and benazepril group（benazepril only）. Their therapeutic effects were recorded and analysed. Results Twenty -.two hours quantitation of urine protein in the patients of combiational group decreased significantly （ P 〈0.01 ） , whereas blood albumin increased greatly （ P 〈0.01 ） one month after therapy. Meanwhile BUN decreased more in combinational group than that of benazepfil group （ P 〈 0.01 ）. The SCr in combinational group were less than that of benazepril group post - treatmently （ P 〈 0. 05 ）. Conclusion The schedule of fleabane injection combined with astragalin injection and benazepril can palliate albuminuria, ameliorate and stablize renal function of patients with IgA nephropathy and chronic renal insufficency,with a better therapeutic effect than using benazepril singly.