黄蘑碱提物对X射线照射小鼠免疫功能的保护作用

Protective effect of Alkali Extract of Huangmo (AEHM) on immunological function in X irradiated mice

本文观察了预防给予黄蘑碱提物对受２．０ＧｙＸ射线单次全身照射后２４ｈ小鼠免疫功能的影响。结果表明，黄蘑碱提物可明显增加受照小鼠脾、胸腺细胞数，减轻其指数的降低，显著增加脾脏淋巴细胞对ＣｏｎＡ诱导增殖反应和胸腺细胞自发增殖反应的能力；黄蘑碱提物可使正常小鼠的上述指标均有增加趋势；与人参多糖辐射防护作用类似。提示，黄蘑碱提物不仅对辐射所致的免疫功能损伤有保护作用，也可增强机体的防御能力，作为免疫增强剂应用于临床是很有希望的。

The male mice were given ip AEHM 5 mg/kg,wt/d before irradiation with 2.0 Gy X rays for 3 days,and the changes of several immunological indexes were observed 24 h after X irradiation.The results showed that AEHM significantly increased the numbers of splenocytes and thymocytes,the reaction of splenocytes to ConA and the spontaneous proliferaion of thymocytes in irradiated mice,and decreased the fall of spleen and thymus.In addition,a tendency of the increases in the above indexes in the intact mice treated with AEHM was observed.Meanwhile,AEHM possessed similar radioprotective effect on immunological functions to polysaccharides of Ginseng.The results suggest that AEHM has not only a radioprotective effect on immunological functions in the irradiated mice,but also an enhancing effect on the defence functions in the intact mice It is very hopeful that AEHM acted as immune enhanced drug should be used in the clinic.