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普罗布考对急性冠状动脉综合征患者血管内皮损伤的干预效应 被引量:12

Beneficial effects of probucol on endothelial function in patients with acute coronary syndrome
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摘要 目的观察普罗布考早期治疗对急性冠状动脉综合征(ACS)患者的血管内皮功能的影响。方法49例ACS患者随机分为两组,普罗布考组(P组,n=24)和常规治疗组(C组,n=25),检测外周血氧化低密度脂蛋白(ox-LDL)、一氧化氮(NO)及循环内皮细胞(CEC)数量,应用高频超声测肱动脉内皮依赖血管舒张功能(FMD),用药治疗3个月,观察治疗前后指标变化。结果P组患者治疗后与治疗前相比,外周血中ox-LDL和CEC水平明显降低(P<0.01),NO含量明显升高(P< 0.01),FMD明显升高(P<0.05)。P组患者治疗后与C组相比,外周血中ox-LDL和CEC水平明显降低(P<0.01,P<0.05),NO明显升高(P<0.01),FMD明显升高(P<0.05)。C组CEC、NO含量及FMD含量治疗前后差异无统计学意义(P>0.05)。P组治疗后血浆ox-LDL与CEC呈正相关(r= 0.385,P<0.01),与NO FMD呈负相关(r=-0.517,P<0.01)。结论普罗布考具有抗氧化、降低ox-LDL,提高ACS患者血管内皮功能的作用。 Objective The study investigate the antioxidant probucol on endothelial function in patients with acute coronary syndrome ( ACS). Methods A total of 49 ACS patients randomly received standard therapy plus probucol ( P, n = 24) or standard therapy ( C, n = 25 ). Plasma oxidized low-deusity lipoprotein (ox-LDL), nitric oxide (NO) and circulating endothelial cells (CEC) were measured. The brachial arterial hyperemia-induced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilatafions were measured by high resolution ultrasound. These variables were analyzed before and after 3 months therapy. Results Plasma NO and FMD was significantly increased after 3 months therapy than before therapy [ (80. 46 ± 10. 24)μmol/L vs (48.46 ±12. 24)μ mol/L, P 〈0. 01 ; ( 13.46 ± 1.20)% vs (7.45 ± 1.02) %, P 〈 0. 05, respectively ], while the number of CEC and ox-LDL were signiicamtly decreased (P〈0.01) in P group. These values were similar before and after 3 months in C group. The linear correlation analysis showed that plasma ox-LDL negatively correlated with NO ( r = - 0. 574, P 〈 0.01) and FMD (r = -0.517,P 〈0.01) and positively correlated with CEC(r =0.385,P 〈0.01) in patients received 3 months prohucol therapy. Conclusions Chronic antioxidant prohucol therapy could improve endothelial function in patients with ACS.
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2006年第7期609-612,共4页 Chinese Journal of Cardiology
基金 国家自然基金资助项目(30470729)
关键词 冠状动脉疾病 内皮 血管 降血脂药 Coronary disease Endothelium,vascular Antilipemic agents
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参考文献13

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