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204对不孕夫妇支原体感染临床分析 被引量:10

Clinical Analysis the Ureaplasma Urealyticum Infection in 204 Infertile Couples
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摘要 目的:探讨不孕夫妇支原体感染状况并对两者相关性进行分析。方法:调查对象为204对不孕夫妇,PCR技术检测男女方衣原体感染情况,培养方法检测支原体。结果:①男女性支原体阳性率分别为8.8%(18/204)和27.9%(57/204),衣原体阳性率分别为2.9%(6/204)和3.9%(8/204);在同性别中,支原体感染率显著高于衣原体,P>0.01;女性支原体感染率显著高于男方。②输卵管阻塞者支原体感染率高达40.3%(53/132),非输卵管阻塞者支原体为5.5%(4/72),两者相比有显著性差异,P<0.01。③不孕年限≤5年组中,女性支原体阳性率为30.9%(26/84);>5年组中,支原体阳性率为24.2%(29/120),两者相比无显著性差异。④支原体药敏试验敏感率由高至低分别为克拉霉素94.7%(71/75)、交沙霉素84.0%(63/75)、阿齐霉素84.0%(63/75)、强力霉素80.0%(60/75)、罗红霉素74.7%(56/75)美满霉素61.3%(46/75)。结论:不孕症夫妇中女性支原体感染率高,应重视治疗;支原体治疗所推荐使用的药物有克拉霉素、交沙霉素、阿齐霉素、强力霉素。 Objective: To research the infection rate of ureaplasma urealyticum in infertile couples and the relationship between the pathogen and the infertility. Methods: 204 infertile couples were investigated, PCR method was used to detect the chlamydia trachomatic ( CT), culture method was used to detect the ureaplasma urealyticum (UU) . Results: (1) the positive rates of UU in male and female were 8. 8% (18/204) and 27. 9% (57/204) , the positive rates of CT were 2. 9% (6/204) and 3. 9% (8/204) respectively. The infection rates of UU in homogeneity were higher than CT, P 〉0. 01. The positive rate of UU in female was higher than that in male; (2) The infection rate of UU in tubal blocked and unblocked female patients were 40. 3% (53/132) and 5. 5% (4/72) respectively, P〈0. 01 ; (3) In the group which the infertile years less than 5, the UU positive rate was 30. 9% (26/84), In those longer than 5 years, the UU rates was 24. 2% (29/120) , there was no obvious difference between the two groups; (4)The UU susceptibility to antibiotics analysis results showed that the sensitivity rates of clarithromycin glutamate, Josamycin, Azithromycin Sodium Dihydrogen Phosphate Doxycycline, roxithromycin and Minocycline were 94. 7% (71/75) , 84. 0% (63/75) , 84% (63/75) , 80% (60/75) , 74. 7% (56/75) and 61. 3% (46/75) respectively. Conclusion: the UU infection rate in infertile female is high, it is necessary to therapy the pathogen. The clarithromycin glutamate, Josamycin, Azithromycin Sodium Dihydrogen Phosphate and Doxycycline were recommended to be used.
作者 周红霞
出处 《中国妇幼保健》 CAS 北大核心 2006年第15期2110-2111,共2页 Maternal and Child Health Care of China
关键词 不育不孕 支原体 感染 Infertility Ureaplasma urealyticum Chlamydia trachomatic
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