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栀子对急性胰腺炎大鼠胰腺细胞亚细胞器的保护作用 被引量:36

Protective Effect of Fructus Gardeniae on Pancreatic Subcellular Organs of the Acute Pancreatitis in Rats
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摘要 本实验利用去氧胆酸钠胰管内注射诱发大鼠急性胰腺炎(AP),以琥珀酸脱氢酶(SDH)、酸性磷酸酶(ACP)、细胞色素P450分别作为线粒体、溶酶体和微粒体的标志酶,检测AP时胰腺细胞亚细胞器的功能变化及栀子的影响,并就组织学的变化作了同步观察。结果显示:AP动物胰腺细胞内SDH明显降低,ACP释放率显著升高,栀子治疗组SDH与正常接近,ACP释放率明显降低,P450增高。组织学检查表明AP动物的胰腺组织有明显的炎症改变,亚细胞器结构异常;用栀子治疗者,病变明显减轻。提示栀子对AP时胰腺细胞亚细胞器的功能、结构均有良好的保护作用。 The acute pancreatitis(AP) was induced with sodium deoxy-cholate in SD rats.Succinic dehydrogenase(SDH),acid phosphatase(ACP) and cytochrome P450 were taken as marked enzyme in estimation of mitochondria,lysosome and microsome to observe the functional and structural changes of the pancreatic subcellular organs and the protective effects of Fructus Gardeniae(FG)in acute pancreatitis in rats.The histological change was observed simultaneously.The results showed that pancreatic cellular SDH reduced significantly and the releasing rate of ACP raisedobviously in AP,in FG treated group,SDH was nearly the same as in normal,the releasing rate of ACP decreased and the content of P450 increased in the same time.Histologic observation showed that there was significant inflammatory change in pancreas and abnormal manifestation in structure of subcellular organs in AP.FG Could alleviate the lesion. These results suggested the FG has a remarkable protective effect on the function and structure of the pancreatic subcellular organs in AP.
机构地区 大连医科大学
出处 《中国中西医结合杂志》 CAS CSCD 北大核心 1996年第6期355-357,共3页 Chinese Journal of Integrated Traditional and Western Medicine
基金 国家自然科学基金 国家中医药管理局重点课题
关键词 胰腺炎 栀子 线粒体 溶酶体 保护作用 pancreatitis,Fructus Gardeniae,mitochondria,lysosome,microsome
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参考文献2

  • 1高静涛,大连医学院学报,1989年,11卷,4期,27页
  • 2张春明,中国地方病学杂志,1987年,6卷,4期,238页

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