不同浓度氟化钠液对脱矿牙釉质的再矿化作用

Effects of sodium fluoride on dental enamel demineralization

目的通过观察不同浓度氟化钠对脱矿牙釉质表面显微硬度值的影响,进一步探讨其对脱矿牙釉质的再矿化作用。方法将牙釉质标本随机分为4组,制成人工龋模型,分别以0.025 mol/L NaF液、0.05 mol/L NaF液、0.1 mol/L NaF液及去离子水处理后测定釉质表面显微硬度值。结果实验前后各组均数间进行配对检验,结果1、2组间在处理前后差异有显著性(P<0.01),实验3组与对照组间在处理前后差异无显著性(P>0.05);实验后各组均数间进行One-Way-Anova分析,各组间差异有显著性(P<0.01),进行SNK-q检验,实验1、2组,1、3组,1、4组间差异有显著性(P<0.05),实验2、3组,2、4组间差异有显著性(P<0.01),实验3、4组间差异无显著性(P>0.05)。结论在一定界值氟化钠浓度下,脱矿牙釉质再矿化作用随着浓度增加,高于这个界值时增加不明显甚至有所下降,因此建议临床上局部用氟的浓度不应大于0.05 mol/L,低浓度的氟有助于临床上牙釉质脱矿的防治。

Objective To explore the effect of remineralization of different concentration NaF on demineralized enamel by investigating the variety of microhardness of demineralized enamel. Methods The artificial caries model was made with acidulous gel. The demineralized enamel specimens were randomly divided into 4 groups, according to the NaF level （mol/L） ： 0. 025,0.05,0.1 and deionized water as control. The microhardness of specimens was detected after treatment. Results The result between pre and post- soaks was compared with matched pair t test. There was significant difference between groups 1 and 2（ P 〈 0.01 ）, but not between group 3 and control group（ P 〉 0.05）. Analysis of variance showed that difference between groups was significant （ P〈 0.01 ） after treatment. SNK-q analysis showed there was significant difference between groups 1 and 2,1 and 3, 1 and 4（P〈0.05）, 2 and 3,2 and 4 （P 〈 0.01 ）, but not betecen group 3 and control group（P 〉 0.05 ）. Conclusion NaF can improve microhardness of enamel surface at a lower value（0.05 mol/L）. When the value is higher than 0.05 mol/L, the NaF effect is not obvious, even lower, suggesting that lower NaF（〈0.05 tool/L） can prevent and treat the demineralization enamel.