儿童1型糖尿病32例临床分析

Clinical analysis of type 1 diabetes mellitus in 32 children

目的:探讨儿童1型糖尿病(type 1 d iabetes m ellitus,T1-DM)的临床特点,以提高对儿童1型糖尿病的诊治和管理水平。方法:回顾分析32例1型糖尿病患儿的临床资料,并观察10例糖尿病酮症酸中毒(d iabetes ketoaacdosis,DKA)患儿的诊治效果。结果:10例儿童1型糖尿病首发症状为酮症酸中毒,4例以呼吸道感染、3例以呕吐、1例以腹痛为首发表现;小剂量胰岛素短时静脉滴注治疗DKA效果好。结论:儿童1型糖尿病起病往往隐匿,临床表现不典型,以酮症酸中毒及呼吸、消化系统疾病为首发表现就诊者,易误诊误治;胰岛素治疗有效。

Objective：To evaluate the clinical manifestation of diabetes mellitus in children and to improve the clinical diagnosis and management in children with type 1 diabetes mellitus （ T1-DM ）. Methods ： The clinical data of 32 children diagnosised as T1-DM between 1999 and 2006 in Anhui Provincial Children＇s Hospital were retrospectively analyzed, and the treatment outcomes of diabetes ketoacidosis（DKA） in 10 children were observed. Results： The preliminary symptoms of T1-DM were DKA in 10 patients, respiratory infection in 4 patients, vomiting in 3 patients and stomachache in one patient. The low-dosage insulin was effective to children with DKA. Conclusions：The onset of the T1-DM in children is usually latent with atypical clinical manifestations. The DKA, the respiratory and digestive diseases are the preliminary symptoms. Therefore it can be easily misdiagnosed and treated in wrong way. The insulin is effective to it.