摘要
报道了二氢埃托啡透皮贴片系统（ＤＨＥ－ＴＤＳ）的研制情况，并对该系统进行了初步动物实验，结果说明，以ＰＶＡ，ＰＶＰ、乳糖等为主要基质制成的ＤＨＥ－ＴＤＳ对皮肤的刺激性属轻度，用家兔腹部贴片。测定药库中药物剩余量，结果推知药物释放符合一级原理。大鼠实验证明，ＤＨＥ－ＴＤＳ稳定释药时间为用药后４一３２ｈ，大鼠扭体实验证明ＤＨＥ－ＴＤＳ一次用药，镇痛作用持续时间至少４８ｈ。此制剂是否有成瘾性，尚待证明。
A transdermal delivery system of dihydroetorphine hydrochloride(DHE-TDS)wasdeveloped.The DHE-TDS mainly composed of polyvinyl alcohol,polyvinyl pyrrolidone and lactose.Tests on rabbits showed only slight skin irritation according to federal hazardous substances act Bygiving DHE-TDS to rabbits, DHE release was shown to be governed by first-order mechanism. WhenDHE-TDS was given to Wistar rats,a relatively stable blood drug concentration was observed from 4～32 h after drug adminstration. Writhing tests showed that one dose of DHE-TDS would maintainthe narcotic action on rats for at least 48 h.
出处
《药学学报》
CAS
CSCD
北大核心
1996年第10期770-774,共5页
Acta Pharmaceutica Sinica
关键词
二氢埃托啡
透皮给药系统
扭体实验
Dihydroetorphine hydrochloride
Transdermal drug delivery system
Writhing tests
