经尿道电切联合吡柔比星膀胱灌注与单纯经尿道电切治疗腺性膀胱炎的临床随机对照试验

Randomized controlled trial of transurethral resection combined with bladder instillation of pirarubicin and only transurethral resection for treatment of cystitis glandularis

目的评价经尿道电切联合吡柔比星灌注膀胱与单纯经尿道电切治疗腺性膀胱炎的疗效与安全性差别。方法69例腺性膀胱炎患者随机分成两组,33例行经尿道电切联合膀胱灌注吡柔比星(联合组),36例单纯行经尿道电切(对照组)。结果联合组有效率明显高于对照组,联合组的轻微不良事件发生率亦高于对照组。结论经尿道电切联合吡柔比星膀胱灌注治疗腺性膀胱炎优于单纯行经尿道电切。

Objective To evaluate the difference of effectiveness and safety between transurethral resection combined with bladder instillation of pirarubicin and transurethral resection only in treatment of cystitis glandularis. Methods The study included 69 consecutive patients with cystitis glandularis. All patients were randomly allocated to combined group treated with transurethral resection combined with bladder instillation of pirarubicin and control group treated with transurethral resection only. Results The transurethral resection combined with bladder instillation of pirarubicin group had a higher cure rate than the only transurethral resection group. On the other hand, the incidence of the adverse effects in the former was higher than those in the latter,though not serious. Conclusion The transurethral resection combined with bladder instillation of pirarubicin is more effective than the only transurethral resection in treating cystitis glandnlaris.