摘要
目的比较西酞普兰与阿米替林治疗老年抑郁症的疗效及不良反应。方法将72例符合CCMD-3诊断标准的老年抑郁症病人随机分为两组,分别采用西酞普兰和阿米替林治疗8周,采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和副反应量表(TESS)评定疗效和不良反应。结果西酞普兰组疗效优于阿米替林组(uc=1.81,P〈0.05),副作用轻于阿米替林组(t=5.01~15.91,P〈0.05、0.01)。结论西酞普兰是一种既有效又安全的新型抗抑郁药,适用于老年抑郁症的治疗。
Objective To compare the therapeutic effects and side effects of eitalopram and amitriptyline in the treatment of senile depression. Methods Seventy-two patients confirmed to CCMD-3 standards were randomized evenly to eitalopram group and amitriptyline group. They were given eitalopram or amitriptyline for eight weeks. The therapeutic effects and side effects were evaluated by HAMD, HAMA and TESS. Results Citalopram showed better therapeutic effects (uc=1. 81,P〈0. 05 ) and less side effects than amitriptyline (t=5.01-15.91 ;P〈0. 05,0. 01). Conclusion Citalopram is an effective and safe antidepressant in the treatment of the aged depression.
出处
《齐鲁医学杂志》
2006年第4期296-297,共2页
Medical Journal of Qilu