吸烟与肺癌p53、K-ras基因突变关系及性别差异的研究进展

Research Progress of Gender Differences in the Relationship between Smoking and p52、K-ras Gene Mutation in Lung Cancer

吸烟与肺癌p53、K-ras基因突变密切相关,基因突变以G→T颠换为主。性别差异在吸烟所诱导的肺癌p53和K-ras基因突变是否存在易感性的不同,存在不同的观点,但多数人从基因水平上认为女性更容易易感吸烟所致肺癌。对吸烟与肺癌基因突变关系及性别差异的研究,可筛选出易感者,以利于劝其戒烟并可对其进行重点随访,达到降低肺癌发病率的目的。

Smoking is strongly associated with p31 and K-ras gene mutations in lung cancer, of which most are G→T transversions. There are different views, about the susceptibility difference of gender differentiation in p53 and K-ras gcnc mutations in smoking-related lung cancer. However, most people belivc that women arc apt to smoking-related hmg cancer at gene level. Susceptible persons can be selected in the research of gender differentiation in the relationship between smoking and gcnc mutations, to reduce incidence rate of lung cancer by following up and persuading them to give up smoking.