超敏C反应蛋白与尿β_2微球蛋白联合检测对诊断早期糖尿病肾病的临床价值

Clinical value of determination of urinary β_2 microglobulin protein(β_2-MG)and serum/plasma hypersensitive C reaction protein in diagnosis of early stage diabetic nephropathy

目的探讨尿β2微球蛋白(β2-MG)和血超敏C反应蛋白(HS-CRP)联合检测对糖尿病早期肾损伤的应用价值。方法用全自动生化分析仪测定89例2型糖尿病患者和50例健康人的血超敏C反应蛋白和尿β2微球蛋白含量。结果糖尿病组β2-MG和HS-CRP明显高于健康人组(P<0.01),且联合检测阳性率达89.9%,明显高于单项检测。结论尿β2-MG与血HS-CRP是糖尿病早期肾损伤的敏感指标,联合检测更为敏感。

Objective To study the clinical value of determination of urinary β2microglobulin （β2-MG） and hypersensitive C reaction protein （HS-CRP） in diagnosis of early stage diabetic nephropathy. Methods β2-MG and HS-CRP in 89 patients with type Ⅱ diabetes and 50 healthy subjects were measured by automatic biochemical analyzer. Results Compared with healthy control group, the urinary β2-MG and HS-CRP in diabetic nephropathy group were significantly higher （P 〈 0.01）, and the positive rate in determination of β2-MG and HS-CRP combined together was significantly higher （89.9 %） than either one. Condusion The level of β2-MG and HS-CRP are sensitive parameters in early stage of diabetic nepropathy especially in combined determination of both levels.