摘要
目的：利用血氧水平依赖性功能性磁共振成像(BOLD-fMRI)技术及非金属MRI专用眼镜。分析探索屈光不正对儿童大脑皮层视觉功能区神经元活动的影响。方法：以1．5T磁共振成像系统采集8例屈光不正眼儿童屈光矫正前后枕叶视皮层兴趣区BOLD-fMRI数据,及8例正常眼凸透镜离焦前后枕叶视皮层兴趣区BOLD-fMRI数据,进行对比分析,比较屈光不正眼及其矫正后、正常眼及其离焦后皮层视觉功能区神经元活动的不同,分析其改变特点及原因。结果：屈光不正眼儿童矫正屈光后皮层视觉功能区神经元活动范围明显增加(p＜0．05)；正常眼离焦后皮层视觉功能区神经元活动范围明显减小(p＜0．05)。结论：屈光不正会明显降低儿童皮层视觉功能区的神经元活动。屈光不正患儿应尽早配镜矫正,以免影响视觉皮层功能发育。
Objective： To explore ametropia＇s influence on children＇s visual cortex by using BOLD - fMRI technology and non - metal glasses. Methods： Bold-fMRI technique with 1.5T SIMENS SONATA MRI was used. BOLDfMRI activation maps of 8 ametropia eyes before and after ametropia correction were collected respectively, BOLD - fMRI activation maps of 8 nomkal eyes before and after defocusing were collected respectively, Results： After ametropia correction,the neure activity in the functional area of visual cortex of children with ametropia increased obviojsly（p 〈 0.05）; while that of children with normal eyes, decreased（P 〈 0.05）. Conclusion： Ametropia can decrease visual cortex neure activity apparently. So children with arnetropia should be worn glasses as early as possible to correct ametropia, or else it will affect the tractional development of visual cortex.
出处
《现代生物医学进展》
CAS
2006年第9期47-49,共3页
Progress in Modern Biomedicine
