期刊文献+

糖皮质激素对重症肌无力患者周围血IL-2活性及sIL-2R水平的影响 被引量:4

Effecting of GC on the IL-2 Production of PBMC and the Serum Level of sIL-2R in Patients with MG
下载PDF
导出
摘要 检测了42例重症肌无力(MG)患者周围血单个核细胞(PBMC)白细胞介素-2(IL-2)活性及血清可溶性白细胞介素-2受体(sIL-2R)水平,重点观察了14例MG患者在糖皮质激素(GC)治疗后IL-2活性及sIL-2R水平变化。结果显示,MG患者PBMCIL-2活性显著低于正常对照组,而血清sIL-2R水平显著高于正常对照组,且MG患者IL-2活性与sIL-2R水平之间呈显著负相关;应用GC治疗后,IL-2活性显著升高,sIL-2R水平显著下降。提示MG患者IL-2活性变化与sIL-2R水平密切相关,GC可通过影响IL-2活性及sIL-2R水平而发挥免疫治疗作用。 The production of IL-2 of peripheral blood mononuclear cells(PBMC)and the level of sIL-2R in serum were measured in 42 myasthenia gravis(MG)patients and 40 normal controls(NC),measured again in 14 of all MG patients after using glucocorticosteroids(GC).The results showed that the production of IL-2 of PBMC from MG patients was much lower than that from NC while the level of sIL-2R in serum of MG patients was much higher than that of NC.They were significantly negatively correlated.The production of IL-2 of PBMC was significantly increased while the level of sIL-2R in serum was significantly decreased in 14 MG patients after using GC.These results indicate that the IL-2 production of PBMC is related to the level of sIL-2R in serum of MG patients.The immunological inhibitory role of GC on MG patients is played by effecting production of IL-2 and sIL-2R.
出处 《中国神经免疫学和神经病学杂志》 CAS 1996年第3期168-171,共4页 Chinese Journal of Neuroimmunology and Neurology
关键词 重症肌无力 糖皮质激素 白细胞介素-2 受体 myasthenia gravis IL-2 sIL-2R glucocorticosteroids
  • 引文网络
  • 相关文献

参考文献1

共引文献272

同被引文献28

引证文献4

二级引证文献17

;
使用帮助 返回顶部