红花提取物对高脂血症大鼠降脂和抗氧化的实验研究

Experimental Study on Regulation of Lipid Metabolism and Antioxidation by Extract of Carthamus Tinctorius L. in Hyperlipidemia Rat

目的采用大鼠高脂血症模型观察红花提取物降血脂、抗氧化及对血液流变学指标的影响。方法采用高脂饲料喂养大鼠造成高脂血症模型,口服给药一个月后,腹主动脉采血,分别用非抗凝血和抗凝血测定TG,TC,LDL,全血黏度,血浆黏度,红细胞压积,血清MDA,SOD和NO。结果红花水提物明显降低高脂血症大鼠TC,TG,LDL-C;醇提物降低TC;两种提取物均降低高脂血症大鼠血浆黏度及MDA含量;醇提物使SOD活性升高。结论红花提取物对高脂血症大鼠具有一定的降脂作用,降低血浆黏度,同时提高机体抗氧化能力。

Objective： To observe the effects of extract from Carthamus tinctorius L on regulation of lipid metabolism, hemorheological indexes, antioxidation in rat with hyperlipidemia. Methods： Using hyperlipidemia animal model replicated by hyperlipidemia forage,TC, TG, HDL, LDL, hemorheological indexes, levels of MDA, SOD, NO were assayed. Results：The levels of TG, TC, LDL-C in all groups treated with the water extract of Carthamus tinctorius L. were significantly reduced. The alcohol extract of Carthamus tinctorius L. showed a decreased action for TC and increased one for SOD activity; For the two extracts, the decreased plasma viscosity and content of MDA were found. Conclusions： The extract of Carthamus tinctorius L. regulated the lipid metabolism, improved hemorheological indexes, increased the activity of scavenging free radicals in rat with hyperlipidemia.