哮喘患儿血清ECP、T-IgE及外周血嗜酸性粒细胞水平和临床意义

Levels of serum ECP,T-IgE and EOS in asthmatic children and their significance

目的探讨支气管哮喘患儿血清嗜酸性粒细胞阳离子蛋白(eosinophil cationonic protein,ECP)、血清总免疫球蛋白E(total immunoglobuline E,T-IgE)及外周血嗜酸性粒细胞(eosinphils,EOS)水平及临床意义。方法采用荧光酶联免疫法测定32例支气管哮喘患儿治疗前后血清ECP、T-IgE水平及EOS按常规法计绝对数。结果哮喘急性发作组血清中ECP水平明显高于缓解期组和正常组,ECP水平的升高程度与病情严重程度相关,且两者之间呈正相关。哮喘组血清T-IgE水平明显高于对照组,哮喘急性发作期与缓解期无显著差异。而3组的EOS计数无显著性差异。结论ECP是EOS活化后脱颗粒释放的主要炎性介质,是反映支气管哮喘气道炎症发生发展的重要指标之一,血清ECP含量的变化与哮喘患儿疾病的状态有关,具有重要的临床价值。

Objective To explore the roles and clinical significance of eosinophil cationic protein （ECP）, total immunoglobuline E （T- IgE） and perpheral blood eosinophil （EOS） count in children with asthma. Methods The serum levels of ECP and T - IgE concentration were studied in 32 asthmatic children before and after treatment and in 10 healthy controls by flu- Eosinophil count was made at the same time. Results The serum level of ECP in patients with acute asthma was much higher than that in the patients in remission and in the healthy controls. The serum ECP was related to the severity of asthmatic symptom. The serum T - IgE was significantly higher in asthmatic children than in controls, but no significant difference was found between those in acute asthma and in remission. EOS count showed no differences among the three groups. Conclusion Serum ECP as an important chemokine secreted by activated EOS, can be used to monitor the eosinophilic inflammatory process in the airway, showing the varying status of the bronchial asthma.