猪链球菌2型疫苗研究进展

Progress Toward the Development of a Vaccine Against Streptococcus suis Capsular Type 2

猪链球菌2型可引起人、猪急性败血型、脑膜炎型和关节炎型等传染病,致死率极高,是近年来致病性最强、危害性最大的猪链球菌类型之一。目前因该菌的致病机理不清、抗原类型复杂,限制了疫苗研究的顺利进行。当前在研的猪链球菌2型疫苗类型有死疫苗、弱毒苗、蛋白亚单位疫苗等。

Streptococcus suis capsular type 2 is an important worldwide swine pathogen which causes sepsis, meningitis, arthritis and other serious infections in pigs, and also as a zoonotic agent in humans who occupationally exposed to pigs or pig products. As the most prevalent and the most virulent serotype of the 35 reported Streptococcus suis serotypes in diseased animals, knowledge on the pathogenesis of the infection is poorly understood and the virulence-factor antigens is limited. To date several candidate vaccines against Streptococcus suis capsular type 2, that is killed vaccine, live avirulent vaccine and protein subunit vaccine have been proposed, but no effective vaccine is available.