胶原蛋白的临床应用

CLINICAL APPLICATION OF COLLAGEN

目的为推动胶原蛋白基生物材料向纵深发展,以再评价方式对其在临床医学中得到的广泛而深入的研究与应用进行综述。方法查阅近几年来的相关文献资料,结合多年的工作实践与经验,对胶原蛋白基生物材料的临床研究和应用予以阐述。结果从其生物学性能、质量控制、剂型与临床应用、免疫原性与临床副反应、市场发展潜力5个方面再评价。结论胶原蛋白基生物材料的临床应用具有很大的市场发展空间和潜力。

Objective To review and evaluate the extensive and further research and the application of the collagen-based biomaterials in the field of clinical medicine. Methods The clinical research and application of collagen based biomaterials were comprehensively reviewed and evaluated on the basis of the up-to date publications and our practical experiences in their studies and manufacturing. Results The following five aspects concerned with the collagen-based biomaterials were evaluated： biological property, quality control, formulation of substrate and clinical application, immunogenicity and clinical side effect, and potential of the market development. Conclusion Collgen based biomaterials have a great potential and market space in their clinical application.