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巨细胞病毒与乙肝病毒持续感染的关系 被引量:2

Related Study of Cytomegalovirus and Persistence of Hepatitis B Virus Infection.
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摘要 对感染乙型肝炎病毒(HBV)的个体中巨细胞病毒(CMV)感染的情况进行研究。选取HBV慢性感染或携带者99例,康复组121例,健康对照组60例。分别测定血清CMV-IgG抗体、尿中CMV-DNA及各组相关的生化指标。结果:持续感染组ALT、AST、TBA、Glob高于康复组和正常对照组(P<0.01)。其它指标各组间差异均不显著;三组CMV-IgG阳性率均在95%以上,无显著差异。取对照组中CMV-IgG阳性者的OD均值0.3做为强阳性的cut-off值,三组的CMV-IgG强阳性率分别是65%、51%和40%,持续感染组高于康复组和对照组;三组CMV-DNA扩增结果分别为3例、2例和1例,差别不显著。在受检对象中,按CMV-IgG强阳性与否分组,对HBV的持续感染率进行统计,HBV的持续感染率CMV-IgG强阳性组43%,显著高于非强阳性组27%(P< 0.01)。提示CMV-IgG强阳性是HBV持续感染的危险因素。 To investigate the infections of CMV who have infected HBV and get different results. Three groups: HBV persistence 99, recovery 121 and controls 60 were included. The CMV - IgG in serum and the CMV - DNA in urine and some biochemical parameters were assayed. The results showed that the values of ALT, AST, TBA and Glob were higher in the group of persistent HBV infection than the other two groups ( P 〈 O. O1 ), there were no significant difference in the other parameters between the three groups; We also found the positive rate of CMV - IgG in the three groups was all more than 95% and had no significant difference, but when take O. 3 of the OD as the cutoff value of the strong CMV - IgG positive, the strong positive rate of CMV - IgG in the three groups was 65% ,51% and 40%, respectively, the rate in group of HBV persistence was higher than the other two groups. The results of CMV - DNA in the three groups were 3,2 and 1 case, respectively. And there was no significant difference between them. Within all the subjects, the rate of HBV persistence in the cases which was 43%. This was higher than that of the rest which was 27% ( P 〈0.01 ). The strong positive of CMV - IgG is a risk factor of persistence of HBV infection.
出处 《临床肝胆病杂志》 CAS 2006年第5期336-338,共3页 Journal of Clinical Hepatology
关键词 巨细胞病毒 乙型肝炎 持续感染 cytomegalovirus hepatitis B persistence
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