胃食管反流病与幽门螺杆菌感染的关系研究

Study on the relationship between gastroesophageal reflux disease and Helicobacter pylori

目的:探讨胃食管反流病(GERD)与幽门螺杆菌感染(H.pylori)的关系。方法:将内镜检查确诊的112例GERD患者,按H.pylori检测结果分为H.pylori(+)组和H.pylori(-)组,以内镜下食管炎的分级进行严重度比较。H.pylori(+)组H.pylori根除后与H.pylori(-)组在半年、1年后进行复发率的比较。结果:H.pylori(+)组和H.pylori(-)组GERD重度检出率分别为36.8%(7/19)和63.2%(12/19),差异有显著性。H.pylori(+)GERD患者H.pylori根除后半年、1年食管炎总复发率为70.5%与H.pylori(-)组GERD47.0%比较差异有显著性。结论:H.pylori(-)者GERD重,H.pylori(+)GERD患者H.pylori根除后1年食管炎复发率较高,H.pylori对GERD可能有保护作用。

Objective： To investigate the association between gastro-esophageal reflux disease（GERD） and H. pylori infection. Methods： 112 patients with GERD by endoscopy for the detection of H. pylori were divided into the group with H. pylori（＋） and H. pylori（-）. Comparison of the severe degree of reflux esophagitis by endoscopy and the rate of recurrence between the two groups were performed after eradication of the bacteria in 6 and 12 months. Results： Detectable rate of severe GERD of H. pylori （ ＋ ）, H. pylri （ - ） were 36.8% （7/19）, 63.2 %（ 12/19）, there was signicant difference. The total rate of recur after eradicating H. pylori 6 months, 12 months in H. pylori（＋） GERD was 70. 5%, H. pylori （-） GERD was 47.0%, there was significantly difference. Conclusion： H. pylori （-） GERD was severe. The rate of reurrence in H. pylori （＋） GERD was high after eradicating H. pylori 12 months. H. pylori may has protective effect for GERD.