左旋门冬酰胺酶治疗儿童急性淋巴细胞白血病凝血四项的变化及意义

Variation and significance of coagulation parametesr in L-asparaginase treatment for children with acute lymphoblastic leukemia

目的探讨左旋门冬酰胺酶(L-Asp)治疗儿童急性淋巴细胞白血病(ALL)凝血四项的变化及意义。方法我们对64例应用左旋门冬酰胺酶的急淋患儿治疗前1d、治疗过程中及治疗后2d检测凝血酶时间(TT),活化的部分凝血活酶时间(APTT),血浆凝血酶原时间(PT),血浆纤维蛋白原(FIB)和外周血小板计数(PLT)。结果患儿在使用L-Asp过程中出现凝血四项的异常,主要是对纤维蛋白原的影响较大。结论L-Asp对纤维蛋白原的影响较大,适当补充纤维蛋白原,不影响L-Asp继续应用。

[Objective] To discuss variation and significance of coagulation parameters in L-asparaginasc （L- Asp） treating children with acute lymphoblastic leukemia（ALL）. [Method] We measured thrombin time （TT）, activated partial thromboplastin time （APTT）, prothrombin time （PT）, blood plasma fibrinogen （FIB） and circular platelet count （PLT） in 64 patients with ALL using the L-ASP at 1 day before treatmen4 during the treatment, and at 2 days after the treatment. [Results] Children appeared abnormal coagulation parameters in using the L-ASP, which mainly influences on the fibrinogen, [Conclusion] The L-ASP mainly influences to the fibrinogen, by suitably supplementing the fibrinogen, L-ASP would be continue to apply.