肺癌患者血清P53抗体水平的临床诊断价值

Diagnostic evaluation of serum P53 antibody concentration in lung cancer patients

目的探讨血清P53抗体水平的检测对肺癌的诊断价值和临床意义。方法采用酶联免疫吸附法(ELISA)检测53例肺癌患者和32例经手术或化疗治疗后的肺癌患者血清P53抗体,并以34例健康者和35例肺良性疾病患者血清作对照。结果肺癌组血清P53抗体水平为(4.551±6.074)IU/ml,阳性率为58.5%(31/53),肺癌治疗组血清P53抗体水平为(1.086±2.836)IU/ml,阳性率为25%(8/32),肺良性疾病组为(0.163±0.097)IU/ml,健康对照组为(0.162±0.08)IU/ml;肺癌组与其他三组比较差异均有统计学意义(P<0.01),而肺癌治疗组与肺良性疾病组和健康对照组间比较,差异无统计学意义(P>0.05)。结论P53抗体的出现与肺癌高度相关,可作为肺癌发生的重要标志物,P53抗体的测定有助于肺部良、恶性疾病的鉴别诊断和疗效评价。

Objective Statistically analyze the serum P53 antibody level in lung cancer patients to show its diagnostic values. Methods 53 cases of lung cancer and 32 cases of lung cancer after operalion and chemotherapy are used as study group. 34 normal controls and 35 cases of lung benign disease were used as control group. All the serum P53 antibody levels of the testees are measured with a ELISA kit. Results In 53 cases of lung cancer group, the positive rate was 58.5% （31/53）, while the average sert, m P53 antibody level was （4. 551±6. 074）IU/ml. In 32 cases of lung cancer after treatment including surgical and medical procedures, the positive rate was 25% （8/32）, while the average serum P53 antibody level was （1. 086±2. 836）IU/rnl. In 35 cases lung benign disease group, the average serum P53 antibody level was （0. 163±0. 097）IU/mL. In normal group, the average serum P53 antibody level was （0. 162±0.08）IU/mI.. The lung cancer group had statistical significance in comparison with the other three groups （P〈0.01）. The average serum P53 antibody level among treatment group, benign disease group and normal group had no statistical significance（P〉0.05）. Conclusion The P53 antibody＇s appearance is highly correlated with lung cancer. It can be used as an important marker of lung cancer and be beneficial to the differential diagnosis of lung lesions and the evaluation of the treatment.