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六味地黄丸 银杏叶片对早期2型糖尿病胰岛素抵抗与脂毒性的影响 被引量:4

Influence of Liuweidihuang Pills and Ginkgo Biloca Leave to the Lipotoxicity and Insulin Resistance in Early Time of Type 2 Diabetes Mellitus
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摘要 目的:评价在西药降糖降压基础上,中药对早期2型糖尿病胰岛素抵抗与脂毒性的影响。方法:采用随机、双盲、安慰剂对照的试验方法。单纯西药与中西药合用组的比例为1∶1。纳入试验例数108例,实际完成观察例数104例,其中试验组53例,对照组5 l例。每1个月复诊1次,疗程为6个月。观察指标包括疗效性指标如主要临床症状、空腹血糖(FBG)、餐后2h血糖(PBG)、血压(BP)、糖化血红蛋白(HbA1 c)、血清胆固醇(TC)、甘油三酯(TG)、游离脂肪酸(FFA)、肿瘤坏死因子α(TNFα)、空腹胰岛素(FIns)。结果:六味地黄丸、银杏叶片能够调节血脂代谢,减轻脂毒性,中西药合用组TC、TG、LDL-C、HDL-C、FFA和TNFα均优于单纯西药组,两组比较差异无显著性;其中FFA和TNFα自身前后比较差异有统计学意义。中西药合用组在改善胰岛素抵抗(IR)方面略优与单纯西药组,差异无显著性。 Objective: To evaluate the influence of the Chinese traditional medicine to the Lipotoxicity and insulin resistance in early time of type 2 diabetes mellitus on the base of using west medicine. Methods: A randomized, doubledblind and placebo controlled trial was conducted. The group used west medicine simplifies and the other one combined with Chinese medicine are in the ratio of 1 to 1. One hundred and eight patients were admitted in the test. And one hundred and four finished the whole investigation. Among these patients, fifty - three were divided randomly into the Chinese and west medicine group and others into the west medicine group. The whole course of treatment is six months with subsequent visit every month. The observed indices include both curative effect indices,such as clinic symptoms, FBG, 2hPBG, BP HbA1, TC, TG, FFA,TNF-α and F- Ins. Results: Liuweidihuang pills and Ginkgo biloca leave preparations have the trend of regulating the blood lipid metabolism,reduction lipotoxicity and insulin resistance(IR) in the west and Chinese medicine group ,in which TC, TG, LDL- C, HDLC, and FFA and TNF -α though without statistical difference compared with the control group. But it can reduce FFA and TNF - α with statistical difference compared with the themselves group in former and behind. Conclusion: Liuweidihuang pills and Ginkgo biloca leave preparation can regulate the blood lipid metabolism reduces lipotoxicity and have the trend of reduction IR.
出处 《辽宁中医杂志》 CAS 北大核心 2006年第11期1423-1426,共4页 Liaoning Journal of Traditional Chinese Medicine
基金 江苏省科学厅科技示范工程招标项目(BS2003056)
关键词 2型糖尿病 六味地黄丸 银杏叶片 阴虚热盛证 中医药疗法 对照观察 type 2 - diabetes mellitus Liuweidihuang pills Ginkgo biloca leave preparation deficiency of yin and excessive heat syndrome: TCM theraoeutics: comparative observation
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