表皮生长因子受体在老年大肠癌中的表达及临床意义

Expression of epidermal growth factor receptor in geriatric large intestine carcinoma and its clinical significance

目的探讨表皮生长因子受体(EGFR)在老年大肠癌组织中的表达及其临床意义。方法采用免疫组化SABC法对87例大肠癌、14例大肠炎性黏膜和26例大肠腺瘤样息肉进行检测。结果EGFR在大肠炎性黏膜、腺瘤样息肉和大肠癌中阳性率分别为21.43%、46.15%和54.02%,其中EGFR在炎性黏膜中表达率明显低于腺瘤样息肉和大肠癌(P<0.05);EGFR表达与大肠癌浸润深度和淋巴结转移有相关性(P<0.05)。结论EGFR过度表达,在老年大肠癌的发生过程中可能起重要作用;检测EGFR对于指导临床治疗和判断预后有重要意义。

Objective To study the expression of epidermal growth factor receptor （EGFR） in geriatric large intestine carcinoma and its clinical significance. Methods Immunohistochemical method （SABC） was used to detect the expression of EGFR in 87 large intestino careinoma tissues, 14 mucesitis tissues and 26 polypoid adenoma tissues. ResultS The positive rates of EGFR in mucesitis, polypoid adenoma and large intestine carcinoma were 21.43%, 46. 15% and 54. 02%. The expression rates in mucesitis were significantly lower than that in polypcdd adenoma and large intestine carcinoma （P 〈 0. 05）. The expression of EGFR in large intestine carcinoma was related to invasion depth and lymph node metastasis （ P 〈 0. 05 ）. Conclusions The over-expression of EGFR may play important roles in the geriatric large intestine carcinoma. The expression of EGFR in the cancer could play a certain role in judging prognosis and guiding clinical treatment.