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血管加压素在麻醉后心肺复苏中应用的实验研究

Experimental Studies on Antidiuretic Hormone in Ccardiopulmonary Resuscitation after Anesthesia
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摘要 目的观察血管加压素对麻醉后缺氧窒息呼吸心跳停止杂种犬的心肺复苏作用。方法杂种犬19只,体重12~15kg,雌雄不限,全身麻醉持续维持4h。在停用麻药自主呼吸恢复10min后夹闭气管导管,造成缺氧窒息使动物呼吸心跳停止,4min后开始心肺复苏。在行基本生命支持心肺复苏3min后,动物随机分为2组,对照组10只,治疗组9只,对照组心肺复苏方法:给予首剂肾上腺素1mg静推,以后每隔3min重复上述剂量,治疗组心肺复苏首剂给予肾上腺素1mg然后血管加压素18u静推,以后每隔3min重复上述剂量。观察两组自主循环恢复率及自主循环恢复时间。结果治疗组自主循环恢复率88.9%明显高于对照组30%(P<0.05),自主循环恢复时间(8±2.27)min早于对照组(13±1.00)min(P<0.05)。结论血管加压素复合肾上腺素用于麻醉后缺氧窒息呼吸心跳停止心肺复苏有利于复苏成功率的提高,可缩短自主循环恢复时间。 Objective To observe the effects of antidiuretic hormone in cardiopulmonary resuscitation (CPR) for hypoxia - induced cardiac arrest in dogs after anesthesia. Methods 19 dogs weighed between 12-18kg were selected and underwent general anesthesia for 4 hours. 10 minutes after on - set of breath, tracheal tube was clamped to create a hypoxia situation and CPR was commenced 4minutes after cardiac arrest. 3minutess after basic life support, animals were randomly divided into 2 groups, with 10 in control group and 9 in treated group, CPR in control group. Intravenous bolus of lmg epinephrine was administered and then the same dose was repeated every 3minutes. CPR in treatment group, after bolus injection of lmg epinephrine, 18u antidiuretic hormone was administered intravenously, and then the same dose was repeated every 3minutes. The recovery of circulation and recovery time of circulation were recorded in both groups. Results The recovery rate of circulation was significantly higher in treatment group than in control group, and the recovery time is shorter. Conclusions Using antidiuretic hormone with epinephrine in CPR after anesthesia can improve the successful rate of CPR and shorten the recovery time of circulation.
出处 《医学信息(手术学分册)》 2006年第5期57-59,共3页 Medical Information Operations Sciences Fascicule
关键词 血管加压素 肾上腺素 心肺复苏 麻醉 antidiuretic hormone epinephrine cardiopulmonary resuscitation anesthesia
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