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Toll like receptors and inflammatory factors in sepsis and differential expression related to age 被引量:14

Toll like receptors and inflammatory factors in sepsis and differential expression related to age
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摘要 In recent years, the incidence of systematic severe .infection in intensive care units (ICUs) has increased significantly. Sepsis is a" complex, multifactorial syndrome that can develop into conditions of different severity, described as severe sepsis or septic shock. The immunology of severe sepsis and septic shock is poorly defined, despite many studies investigating the pathogenesis of this syndrome. With mortality rates of up to 50%, greater understanding of the interactions between host and microbe is necessary to improve patient outcome. Given the rapid progression of sepsis and immediate recruitment of the inflammatory cytokine cascade, the early innate response of the immune system to the pathogen is likely to play a critical role. In recent years, the incidence of systematic severe .infection in intensive care units (ICUs) has increased significantly. Sepsis is a" complex, multifactorial syndrome that can develop into conditions of different severity, described as severe sepsis or septic shock. The immunology of severe sepsis and septic shock is poorly defined, despite many studies investigating the pathogenesis of this syndrome. With mortality rates of up to 50%, greater understanding of the interactions between host and microbe is necessary to improve patient outcome. Given the rapid progression of sepsis and immediate recruitment of the inflammatory cytokine cascade, the early innate response of the immune system to the pathogen is likely to play a critical role.
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2007年第1期56-61,共6页 中华医学杂志(英文版)
基金 This work was supported by grants from the National Natural Science Foundation of China(No.3037134)
关键词 SEPSIS Toll like receptors age sepsis Toll like receptors age
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