肝衰竭毒邪病因学说辨析

Analysis on Aetiology of Toxin in Hepatic Failure

肝衰竭毒邪病因学说认为,毒邪是肝衰竭的病因,毒邪的范围应包括外毒和内毒两方面。在我国外毒主要指病毒性肝炎,内毒是因外毒入侵导致机体脏腑功能紊乱、气血阴阳失调所产生的对机体有特殊而强烈损伤作用的病理产物,可能涉及T淋巴细胞介导的免疫性“毒”、细胞因子“毒”、炎性因子“毒”、内毒素“毒”、脂质过氧化“毒”等。毒为致病之因,贯穿于疾病的始终,瘀、痰为病变之本,并且毒与瘀、痰又可互为因果,“毒”、“瘀”、“痰”胶结为本病基本病机病理,故相对应的基本治疗原则是解毒、化瘀、祛痰。

The aetiology of toxin in hepatic failure considers that toxins are the etiological factors of hepatic failure, the range of toxins include external toxin and internal toxin. In my country, the external toxin mainly involves in viral hepatitis, internal toxin is a kind of pathological product with fierce injury to body, which can cause the functional disorder of entrails, the disproportion of Qi - blood and yin-yang. It is related with the cell factor, inflammatory factor, endotocin, lipid peroxidation, and so on. The toxin runs through the whole process of disease as the etiological factor, the blood stasis and phlegm are the foundation of pathological changes. The combination of toxin, blood stasis and phlegm is the basic pathogenesis. So, its therapeutic principles are dissipating toxins, dissolving the blood stasis and phlegm.