阿卡波糖治疗2型糖尿病的临床观察研究

Clinical Effect of Acarbose in the Treatment of Type 2 Diabetes Mellitus

目的观察2型糖尿病患者应用阿卡波糖(acarbose,商品名:拜唐苹)对血糖和血浆胰岛素水平的变化。方法40例新诊断的2型糖尿病患者,单用饮食控制后,空腹血糖仍在8～11mmol/L,HbAlc为7％～10％,予拜糖苹50mg．tid治疗16周。结果经16周的治疗,餐后血糖、餐后胰岛素、及胰岛素曲线下面积较治疗前均降低,差异均有显著性。空腹胰岛素、血脂、体重并无明显变化。除极个别患者有腹胀外,单独用药均无低血糖、肝损等不良事件发生。结论阿卡波糖在不增加胰岛β细胞的负荷的基础上,改善了代谢异常和胰岛素分泌紊乱,且具有良好的安全性和耐受性。

Objective To evaluate the clinical effect on blood glucose, insulin and safety ofacarboso in the treatment of Type 2 diabetes Mellitus.Method Forty patients with incipient Type 2 Diabetes insufficiently controlled with diet alone were given acarboso,50mg thrice daily for 16 weeks and the clinical parameters were compared with those before acarboso administration. Results After 16 weeks of acarboso treatment,the postprandial level of blood glucose, insulin as well as the AUC of insulin were significantly decreased.However,the level of fasting blood glucose, blood lipid and body weight of these patients did not change significantly.No serious adverse effects such as hypoglycemia,hepatic dysfunction were observed using acarboso treatment alone except a few patients complained abdominal distension. Conclusion Acarboso are safe and well accepted by restoring the dysfunction ofmotabolism and insulin secretion without increasing the burden of β cell.