摘要
本文采用了先交联制备可溶胀的壳聚糖载体微球,后将模型高分子药物以被动吸咐方式担载在溶胀的微球内的两步法,制备缓释高分子药物微球,避免了高分子药物接触有机试剂引起的活性损失。
In this study the swellable chitosan microspheres were prepared by glutaraldehyed cross-linking reaction.
Model macromolecular followed to be adsorbed into preformed swelling chitosan microsphcre. The two-step synthetic methed for macromolecular drugs slow-release microspheres avoid the problem of macromolecular drug,s biology activity is often compromised by organic agents.
出处
《天然产物研究与开发》
CAS
CSCD
1996年第3期92-95,共4页
Natural Product Research and Development
关键词
药物载体
壳聚糖
微球
缓释
高分子药物
制备
Chitasan
cross-linking,microspheres,slow-release,macromolecular drugs
