期刊文献+

冰片β-环糊精包结物的制备与透皮吸收研究 被引量:7

An In Vitro Study of the Transdermal Absorption of Borneol-β-Cyclodextrin Inclusion
下载PDF
导出
摘要 目的考察冰片经β-环糊精包结后对透皮吸收的影响。方法用NIH系小鼠背部皮肤分别涂布含冰片β-环糊精(-βCD)包结的乳剂和含冰片不包结乳剂,进行透皮吸收试验,用薄层扫描法测定冰片在不同时间点的透过率。考察冰片经β-环糊精包结后对透皮吸收的影响。结果冰片经β-环糊精包结后,透皮速度减慢,持续释药,可防止冰片的挥发,提高了药物稳定性。结论冰片经β-环糊精包结后可透皮吸收,并有缓释作用。 Objective To study the effect of β-yclodextrin inclusion on the transdermal absorption of bomeol in vitro. Methods Depilated skin segments from NIH mice were smeared with emulsion of bomeol β-yclodextrin inclusion and conventional emulsion of bomeol separately. The transdermal absorption of bomeol was assayed in a Franz diffusion cell using thin-layer chromatography to determine the penetration rates of bomeol at different time paints. Results A striking decrease in the rate of transdermal penetration of bomeol that was included by β-yclodextrin was demonstrated. The bomeol-β-yclodextrin inclusion is provided with the property of a sustained-release drug. It prevents the volatilization of bomeol and promotes the stability of the drug. Conclusion Bomeol-β-yclodextrin inclusion can be transdermally absorbed in a sustained-release manner.
出处 《医药导报》 CAS 2007年第2期182-184,共3页 Herald of Medicine
关键词 冰片 Β-环糊精 包结物 透皮吸收 Bomeol β-Cyelodextrin Inclusion Absorption, transdermal
  • 引文网络
  • 相关文献

参考文献4

  • 1国家药典委员会.中华人民共和国药典(一部)[Z].北京:化学工业出版社,2005:附录 37-38.
  • 2董方言.现代实用中药新剂型新技术[M].北京:人民卫生出版社,2001.574-576.
  • 3陆彬.药物新制剂与新技术[M].北京:人民卫生出版社,1998.289.
  • 4秦冬彦,宋洪涛,郭涛,张跃新,张汝华.冰片β-环糊精包合物的稳定性考察[J].中草药,2000,31(4):255-257. 被引量:51

二级参考文献3

共引文献121

同被引文献46

引证文献7

二级引证文献52

;
使用帮助 返回顶部