摘要
目的观察脑血康对实验性脑缺血的保护作用。方法使用小鼠断头模型以及结扎双侧颈总动脉模型,观察断头后张口喘气时间和存活时间;利用结扎大鼠双侧颈总动脉形成急性实验性脑缺血模型,观察脑血康对其脑指数,脑含水量以及毛细血管通透性的影响。结果脑血康对断头小鼠张口动作持续时间有一定的延长作用,但无统计学差异,能显著延长小鼠双侧颈总动脉结扎后的存活时间,并能明显降低缺血模型大鼠脑指数,脑含水量及毛细血管通透性。结论脑血康对实验性脑缺血具有明显的保护作用。
OBJECTIVE To investigate the protective effect of SZNA capsule on experimental cerebral ischemia. METHODS Observing the gasping time and survival time of the mice after decapitation or ligation of the bilateral common carotid artery;Observing the effects of SZNA on the cerebral index,water content of encephalon and the calillary permeability in brain on acute experimental cerebral ischemia induced by the ligation of the bilateral common carotid artery of rats. RESULTS SZNA can prolong the gasping time of the mice after decapitation,but there was no statistic difference;it can significantly prolong the survival time of mice after ligation of the bilateral common carotid artery and decrease the cerebral index,water content and calillary permeability in the brain of rats. CONCLUSION SZNA was effective in protecting experimental cerebral ischemia.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2007年第1期4-6,共3页
Chinese Journal of Modern Applied Pharmacy
基金
国家科技部创新药物和中药现代化课题(2003AA2z3260)
关键词
藏药
脑血康
脑缺血
脑含水量
Tibetan medicine
Sazengnia
Experimental cerebral ischemia
