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四磨汤加山药对早产儿胃食管反流的影响 被引量:2

Effect of the Simotang oral liquid and Shanyao on gastroesophageal reflux in premature infants
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摘要 目的探讨四磨汤口服液加山药对早产儿胃食管反流的影响。方法将45例需经鼻饲管喂养(INGF)的健康早产适于胎龄儿,用同一种配方乳喂养。根据是否辅以四磨汤口服液加山药随机分为两组。记录入液量、奶量、热卡及肠道营养达418.4kJ·kg^-1·d^-1的时间,记录喂养相关情况;同时进行食管24h pH值监测,记录以下指标:24h内总反流次数;反流指数(RI);反流持续时间〉5min次数;pH〈4总时间;最长酸反流时间。结果四磨汤组24h内反流次数明显少于对照组[分别为7(0~24)次,13(6~28)次,P〈0.05];pH〈4的总时间和反流指数与对照组比较明显下降;肠道营养达418.4kJ·kg^-1·d^-1的时间比对照组明显缩短[分别为(11.64±4.23)d,(15.75±4.55)d,P〈0.05]。结论早产儿鼻饲管喂养期间给四磨汤口服液加山药是一种安全简单的辅助喂养方法,可有效的减少胃食管反流次数,对胃肠动力发育有促进作用。 Objective To observe the effect of Simotang(SMT) oral liquid and Shanyao on gastroesophageal reflux(GER) in premature infants. Methods Forty five healthy appropriate-for-gestational-age premature infants (birth weight ranged from 1100g to 2350g,gestational age ranged from 28 weeks to 36 weeks) given intermittent nasogastric feeding(INGF) were randomized into SMT group and N-SMT group according to INGF with or without Simotang and Shanyao, and fed with the same milk formula. The following data were collected and recorded, the fluid intake(including both intravenous and oral), milk intake, caloricintake, time of caloric intake reaching 418.4kJ· kg^-1 · d^-1 by enteral feeding and relevant condition to feeding. Using 24-hour intraesophageal pH monitoring for evaluation of GER, the five parameters of esophageal pH were recorded:number of reflux episodes during 24 hours, reflux index, number of episodes lasting 〉 5min, the duration of the longest episode and the total time of pH 〈 4.Results Forty-two of the 45 infants developed GER,the morbidity was 88.9% ;The number of refluX episodes during 24 hours was significantly fewer in SMT group than that in N-SMT group, P〈 0.05 ;The dahin pH〈 4 and reflux index was lower in SMT than that in N-SMT, there were significant defferences between the two groups, P 〈 0.05. The time of reaching 418.4 kJ· kg^- 1 · d ^- 1 by enteral feeding in SMT group was significantly'shorter than that in NSMT group, P 〈 0.05. Conclusion Simotang and Shanyao used during intermittent nasogastric tube feeding is an easy and safe intervention. Simotang and Shanyao can decrease the number of reflux episodes, has a positive improving effect on the development of gastrointestinal motility, is beneficial to premature infants for establishing postnatal enteral nutrition.
出处 《中国基层医药》 CAS 2007年第2期271-273,共3页 Chinese Journal of Primary Medicine and Pharmacy
基金 山东省枣庄市自然科学基金资助项目(2006-638)
关键词 胃食管反流 四磨汤 署蓣 婴儿 早产 Gastroesophageal reflux Simotang Dioscorea opposita Infant, premature
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