摘要
目的:观察葛根素注射液治疗冠心病心绞痛的疗效及其安全性。方法:采用随机双盲对照法分为治疗组30例(男性11例,女性19例,年龄62±s11a),对照组20例(男性12例,女性8例,年龄66±12a),治疗组以葛根素注射液300mg(对照组仅为该注射液的溶剂)加于5%葡萄糖液500mL中静脉滴注,qd,10d为一个疗程。结果:治疗组对症状的总有效率97%,心电图总有效率60%,高于对照组的45%,30%,(P<0.01,P<0.05),治疗组并有降低血液粘度、血小板聚集率和改善左室舒张功能的作用,而对照组则无上述效应,2组均未见显著不良反应。结论:葛根素注射液是一种安全有效的抗心肌缺血药物。
AIM:To observe the efficacy and safety of iv,drip of puerarin in the treatment of angina pectoris. METHODS:Fifty patients with angina pectoris were randomly divided into treatment group (M 11,F 19;age62±s11 a) and control group (M 12,F8;age66± 12 a) by double-blind method.The treatment group was treated with puerarin 300 mg,while the control group was treated with placebo(solvent of puerarin) ,in 5% glucose 500 mL for iv,drip,qd ×10 d.RESULTS:The clinical and ECG total effective rates of treatment group were 97% and 60%,and those of the control group were 45% and 30%,respectively( P<0.01,P<0.05).Puerarin reduced blood viscosity,diminished platelet aggregating rate,and improved left ventricular diastolic function,No similar effects were found in the control group.There were no marked adverse reactions. CONCLUSION:Puerarin is a safe and effective drug.
出处
《新药与临床》
CSCD
北大核心
1996年第4期207-210,共4页
关键词
冠心病
葛根素注射液
中医药疗法
puerarin
angina pectoris
heart function tests
hemorheology
double-blind method
electrocardiography
echocardiography
intravenous infusions