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丛状神经纤维瘤12例临床病理分析 被引量:5

Plexiform neurofibroma:Clinicopathological analyses of 12 cases
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摘要 目的:探讨丛状神经纤维瘤的临床病理学特征。方法:对12例丛状神经纤维瘤的临床表现、病理学特征进行观察和分析,并结合文献进行讨论。结果:丛状神经纤维瘤一般在儿童期发病,好发头颈部、四肢和躯干。组织学表现为由Schwann细胞、纤维母细胞及胶原纤维构成的丛状结构。免疫组化标记显示:梭形细胞以S-100蛋白阳性为主,vimentin、EMA、NSE或NF散在阳性。结论:丛状神经纤维瘤有特殊的临床病理学特征,提高对丛状神经纤维瘤的认识有助于排查神经纤维瘤病1型。 Objective: To explore the clinicopathological features of plexiform neurofiroma (PNF). Methods: The clinical manifestatous and pathological charactors of 12 cases of PNF were observed and analysed combined with review of the literature. Results:PNF developed in childhood generally and often occurred at head and neck,limbs and trunks. The tumor appeared plexiform pattern consisted of Schwann cells,fibroblasts and collagen fibers. The spindle cells expressed S-100 protein diffusely and vimentin, EMA, NSE and NF scattered. Conclusions:PNF is a tumor with special clinicopathological characteristics ,which is helpful to recognize the neurofibromatosis 1 ( NF1 ).
出处 《蚌埠医学院学报》 CAS 2007年第2期156-158,F0004,共4页 Journal of Bengbu Medical College
关键词 神经纤维瘤 丛状 神经纤维瘤病1型 病理学 临床 neurofibroma, plexiform neurofibromatosis type 1 pathology, clinical
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共引文献11

同被引文献28

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