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不同生长激素激发试验时矮小男童血浆胃促生长素水平 被引量:2

Plasma levels of ghrelin during different hGH provocative tests in boys with short stature
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摘要 对30例矮小男童(20例GH缺乏症和10例特发性矮小症)在不同的激发试验各时间点采血,以放射免疫法测定血浆胃促生长素水平。结果显示,在精氨酸激发试验各时间点血浆胃促生长素水平差异有统计学意义,生长激素释放激素(GHRH)激发试验中血浆胃促生长素峰值与激发后GH峰值呈负相关(P〈0.05)。 Blood samples of 20 boys with growth hormone deficiency (GHD) and 10 boys with idiopathic short stature (ISS) were collected at various time points during different hGH provocative tests. Plasma ghrelin levels were measured by RIA. The results showed that plasma ghrolin levels were different among different time points during arginine stimulation test ( P 〈 0.05 ), and the plasma ghrelin peak were negatively correlated with the stimulated serum hGH peak in GHRH stimulated test (P 〈 0.05 ).
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2007年第1期55-56,共2页 Chinese Journal of Endocrinology and Metabolism
基金 浙江省医药卫生重点项目(2004ZD011)
关键词 胃促生长素 生长激素 侏儒症 Ghrelin Growth hormone Dwarfism
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参考文献5

  • 1Korbonits M,Grossman AB.Ghrelin:update on a novel hormonal system.Eur J Endocrinol,2004,151:S67-S70.
  • 2Zizzari P,Halem H,Taylor J,et al.Endogenous ghrelin regulates episodic growth hormone (GH) secretion by amplifying GH pulse amplitude:evidence from antagonism of the GH secretagogue-R1a receptor.Endocrinology,2005,146:3836-3842.
  • 3Gondo RG,Aguiar-Oliveira MH,Hayashida CY,et al.Growth hormone-releasing peptide-2 stimulates GH secretion in GH-deficient patients with mutated GH-releasing hormone receptor.J Clin Endocrinol Metab,2001,86:3279-3283.
  • 4Giavoli C,Cappiello V,Corbetta S,et al.Different effects of short-and long-term recombinant hGH administration on ghrelin and adiponectin levels in GH-deficient adults.Clin Endocrinol (Oxf),2004,61:81-87.
  • 5Jarkovska Z,Rosicka M,Marek J,et al.Plasma levels of total and active ghrelin in acromegaly and growth hormone deficiency.Physiol Res,2006,55:175-181.

同被引文献20

  • 1邵莉,李荣英,张一波,赵双霞,乔洁,朱鋐达,陈名道.不同饥饿时段对常规及高脂饮食大鼠胃壁组织胃促生长素(ghrelin)表达的影响[J].中华内分泌代谢杂志,2005,21(3):265-268. 被引量:7
  • 2潘桂梅,董青,张颖,陈志红,李堂.国产重组人生长激素治疗特发性矮身材患儿的疗效[J].实用儿科临床杂志,2007,22(8):591-592. 被引量:9
  • 3李益卫,赵瑞芳,吴哈,季志英,吕孝妹,顾凡磊,赵晓斐.血清IGF-1和IGFBP-3在矮小症患儿中的诊断意义[J].标记免疫分析与临床,2007,14(2):76-78. 被引量:7
  • 4王慕逖.儿科学[M]5版[M].北京:人民卫生出版社,2001.125-129.
  • 5Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach. Nature, 1999,402:656-660.
  • 6Chanoine JP. Ghrelin in growth and development. Horm Res, 2005,63: 129-138.
  • 7Tena-Sempere M. Exploring the role of ghrelin as novel regulator of gonadal function. Growth Honn IGF Res, 2005,15:83-88.
  • 8Veldhuis JD, Bowers CY. Human GH pulsatility: an ensemble property regulated by age and gender. J Endocrinol Invest, 2003,26:799-813.
  • 9Fumta M, Funabashi T, Kimura F. Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem Biophys Res Commun, 2001, 288:780-785.
  • 10Mastsubara M, Sakatal I, Wada R, et al. Estrogen modulates ghrelin expression in the female rat stomach. Peptides, 2004,25:259-297.

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