放疗对直肠癌组织核仁形成区嗜银蛋白(Agnor)的影响

The effect of radiothrepy to agnor in rectal cancer

目的探讨放疗对直肠癌组织核仁形成区嗜银蛋白(Agnor)的影响。方法选择首次确诊的直肠癌患者32例,均为手术前放疗患者,男18例,女14例。病理类型均为腺癌,病理分级高分化4例;中分化10例;低分化18例。Dukes分期A期3例;B期11例;C期18例。纤维结肠镜于放疗前后取直肠癌组织标本,用免疫组化SP法检测32例直肠癌的Agnor的表达,并进行统计学分析。结果32例直肠癌中放疗后细胞核面积、Agnor数、Agnor面积分别是,10415.1±208.9、1.21±0.28、28.4±15.2,较放疗前321018.1±394.6、4.47±1.05、242.2±35.6明显缩小,各组间比较有显著性差异(P<0.01)。结论放疗对直肠癌的Agnor既明显降低其面积,又明显降低其数目,能控制直肠癌的增殖。

Objective： To investigate the effect of radiotherapy to Agnor in rectcal cancer. Methods： To choose 32 patients with rectcal cancer ,all cases were radiotherapy before operation ,18 cases were male,14 female, 32 cases of rectcal cancer tissues were taken by colonscopy. All the type of pathology were adenocarcinoma,the grading of pathology ：4 cases were wellly differiated adenocarcinoma, 10 cases were middle differiated adenocarcinoma, 18 cases were poorly differiated adenocarcinoma. The staging of Dukes：3 cases were stage A,11 cases were stage B,18 cases were stage C. The rectcal cancer tissue specimens were taken before and after radiotherapy, the expression of Agnor was studied by immunohistochemical method （SP） from 32 cases of rectcal cancer specimens . All data were analysized by Excel statistic software. Results： Surface of cell nuclear of Agnor, number of Agnor,surface of Agnor were respectively 10415 ± 208.9,1.21 ± 0.28,28.4 ± 15.2, before radiotherapy those were respectively 321018.1 ± 394. 6,4.47 ± 1.05,242. 2 ± 35.6, between each group the differences were significant. Conclusion： Radiotherapy can not only reduce the surface of Agnor but also reduce the number of Agnor, radiotherapy can restrain the growth of rectcal cancer.