β-环糊精与左氧氟沙星超分子配合物的合成、表征及其与DNA的结合性质

Synthesis, Characterization and DNA Affinity of the Supermolecule betweenβ-Cyclodextrin and Levoofloxacin

研究了以环糊精为主体,左氧氟沙星为客体的配位反应,用紫外-可见吸收光谱法,分子荧光光度法,差热分析法,X-衍射法等方法对超分子配合物进行了表征,并对超分子配合物的形成进行了初步讨论,实验结果表明:β-环糊精与左氧氟沙星分子形成物质的量比为1:1的超分子配合物。通过β-环糊精超分子配合物的形成,进一步研究了左氧氟沙星与DNA的作用机理,发现它们之间主要作用力是疏水作用。

The interaction between levoofloxacin（guest） and fl-cyclodextrin（host） was studied and also the inclusion complex was charaterized by using UV-visible spectra, fluorescence spectra,DSC and X-ray diffraction. The results indicated that β-cyclodextrin and levoofloxacin had formed the inclusion complex with the ratio of 1 ：1. The mechanics of the interaction between levoofloxacin and DNA,which was hydrophobic interaction, were further investigated.