dsRNA对X射线照射小鼠脾细胞增殖反应和UDS的影响

Effects of dsRNA on proliferative reaction and UDS of splenocytes in X-iradiated mice

本文报道了不同浓度ｄｓＲＮＡ对１．５ＧｙＸ射线照射后小鼠脾细胞对ＣｏｎＡ和ＬＰＳ诱导增殖反应和ＵＤＳ的影响。结果表明，当受照小鼠皮下注射ＲＮＡ浓度大于６．２５ｍｇ／ｋｇ体重时与单纯照射组相比脾细胞对ＣｏｎＡ和ＬＰＳ诱导的增殖反应明显增强（Ｐ＜０．０５），ＵＤＳ亦明显的增加（Ｐ＜０．０５）。提示，ｄｓＲＮＡ可以增强受照细胞对ＣｏｎＡ和ＬＰＳ诱导的增殖反应能力，并能抑制Ｘ射线诱发程序外ＤＮＡ合成的下降。

The effects of different concentratios of dsRNA on proliferative reaction of splenocytes induced by ConA and LPS and on UDS of splenocytes in 1.5Gy X-irradiated mice are reported in this paper.The results showed that the proliferative reaction of splenocytes induced by ConA and LPS in experimental groups increased significantly compared with that in positive group and that UDS in experimental groups was also much enhanced compared with that in positive group when concentration of dsRNA was higher than 6.25mg/kg body weight.It is suggested that dsRNA increases proliferative reaction of splenocytes induced by ConA and LPA and inhibits decrease of UDS induced by X-rays.