摘要
总结我科自1956~1990年内共收治的107例口腔颌面部恶性黑色素瘤病例治疗经验。本组资料显示,该肿瘤好发年龄组为40~59岁组占52.3%,原发于粘膜者占93.5%,皮肤仅占6.5%。好发部位依次是腭部43%,牙龈35%,而唇、舌部少见。除10例失访外(作死亡计算)余下97例患者分别随访3~12年,随访率为92.4%,全组3,5年生存率分别是45.8%,31.8%。死亡病例79例,其中死于局部复发32.8%,远处转移44.3%,淋巴转移6.3%,其它死因占16.5%。比较不同治疗方法的疗效表明:①手术切除原发灶组3,5年生存率均为0%。冷冻治疗原发灶组则为37.5%,31.2%。后者优于前者,有统计学差别。②选择性颈清25例,3,5年生存率为52.6%,30.0%,治疗性颈清37例,其3,5年生存率为40.6%,19.2%,无统计学差异,但提示前者组中患者预后稍好。本组资料颈清病检中淋巴结阳性率高达79.0%。cN_0有53%转移阳性率。作者建议做选择性颈清扫术是必须的。③107例中手术、冷冻及综合治疗三种治疗方法的比较,显示以综合治疗法为最好。因此,作者以为恶性黑色素瘤应该综合治疗,颈清也是必须的。
Abstract From 1956 to 1990,a total 107 patients with oral and maxilofacial melanoma were reated in our department.After operation,97 patients were followed-up for 3~12 years. The 3-year,5-year survival rate was 45.8%,31.8%respectively. There was significant dif- ference between operative group and combined group which included cryosurgery for prima- ry tumor,elective neck dissection,BCG immunological therapy and chemotherapy. It was our experience that combined management should be carried out on patients with oral and maxillofacial melanoma,neck dissection was of importance.
出处
《耳鼻咽喉(头颈外科)》
1996年第5期299-302,共4页
Chinese Arch Otolaryngology-Head Neck Surg