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清眩颗粒对高脂饲料喂养大鼠胸主动脉形态及核因子κB、血小板源生长因子B和碱性成纤维细胞生长因子表达的影响 被引量:2

Effects of Qingxuankeli on Aorta Pathology Morphology and Positive Expression of Nuclear Factor-κB, Platelet Derived Growth Factor-B, Basic Fibroblast Growth Factor of Rat
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摘要 目的探讨清眩颗粒对大鼠主动脉病理形态学及核因子κB、血小板源生长因子B、碱性成纤维细胞生长因子阳性表达的影响。方法选取Wistar大鼠50只,随机分为空白对照组(对照组)、模型对照组(模型组)、清眩颗粒高剂量组(高剂量组)、清眩颗粒低剂量组(低剂量组)、银杏叶片对照组(银杏叶组),每组10只。除对照组喂食基础饲料外,其他各组喂食高脂饲料。喂养8周后,分别灌服蒸馏水、高剂量液、低剂量液、银杏叶片液1ml/100g,连续灌胃4周。检测大鼠胸主动脉病理形态学斑块大小及核因子κB、血小板源生长因子、碱性成纤维细胞生长因子阳性表达。结果清眩颗粒高、低剂量组和银杏叶片组大鼠胸主动脉粥样硬化病变程度较模型组明显减轻。与模型对照组相比,清眩颗粒高、低剂量组、银杏叶片对照组粥样斑块面积与管腔面积之比(分别为21.69±9.86、1.96±1.62、4.25±3.01、5.11±2.82)、胸主动脉壁核因子κB(分别为25.45±4.25、10.53±7.09、16.67±5.56、17.18±6.63,P<0.01)、血小板源生长因子(分别为25.18±8.76、8.32±5.17、12.76±4.38、13.32±5.16,P<0.01)、碱性成纤维细胞生长因子(分别为9.99±1.63、1.41±1.77、4.71±3.90、5.00±2.47,P<0.01)阳性细胞百分比降低,清眩颗粒高剂量组显著低于银杏叶片对照组(P<0.05)。结论说明清眩颗粒对动脉粥样硬化的作用可能与抑制动脉壁核因子κB、血小板源生长因子B、碱性成纤维细胞生长因子阳性表达有关。 Aim Discuss the effection of Qingxuankeli on rat's aorta pathology morphology and nuclear factor (NF- kB), plateled derived growth factc.r (PDGF-B), basic fibroblast growth factor (bFGF) positive expression. Methods Choose 50 Wistar rat,assiga to normal group (feed basic fodder), model group (feed high fat fodder), high dosage Qingxuankeli group (feed high fat fodder), low dosage Qingxuankeli group (feed high fat fodder), ginkgo blade group (feed high fat fodder). After the 8 weeks, distilled water, high dosage Qingxuankeli, low dosage Qingxuankeli, liquid of ginkgo blade was irrigated into stomach separately for 4 weeks in succession. Examine rat's aorta pathology morphology and NF-kB, PDGF-B, bFGF positive expression. Results The degree of aorta scleratheroma pathological change of high, low dosage Qingxuankeli group, ginkgo blade group is slighter than model group obviously . Compared with the model group, the ratio of plaquearea to aortic cavity area (respectively 21.7±9.9, 1.96±1.62, 4.25±3.01, 5.11 ±2.82), the NF-kB (respectively 25.5±4.2, 10.53±7.09, 16. 67±5.56, 17.18±6.63,P〈0.01), PDGF-B (respectively 25.2± 8.8, 8.32±5.17, 12.76±4.38, 13.32±5.16,P〈0. 01 ), bFGF ( respectively 9.99 ±1.63, 1.41 ± 1.77, 4.71± 3.90, 5.00 ±2.47, P 〈 0.01 ) positive cell' s percentage of aorta of the high, low dosage Qingxuankdi group, ginkgo blade group is reduced, the percentage of high dosage Qingxuankeli group is lower than ginkgoes blade group ( P 〈 0. 05 ). Conclusion The function of preventing and curing scleratheroma of Qingxuankeli is related to the fact that Qingxuankeli suppress NF-kB, PDGF-B, and bFGF to express positively.
出处 《中国动脉硬化杂志》 CAS CSCD 2006年第9期778-782,共5页 Chinese Journal of Arteriosclerosis
关键词 病理学与病理生理学 清眩颗粒 动脉粥样硬化 大鼠 胸主动脉病理形态学 核因子ΚB 血小板源生长因子B 碱性成纤维细胞生长因子 Qingxuankeli Scleratheroma Rat aorta pathology morphology Nuclear Factor kB Platelet Derived Growth Factor-B Basic Fibroblast Growth Factor
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