利培酮与传统药物对精神分裂症康复期患者生活质量的研究及其影响因素探讨

The influence of risperidone and conventional antipsychotics on the life quality of the patients with schizophrenia at their recovery stage

目的:探讨利培酮与传统药物对精神分裂症康复期患者生活质量的影响因素。方法:采用人口学资料调查表及世界卫生组织生存质量测定量表来评估利培酮和传统药物两组精神分裂症康复期患者的生活质量,并分析生活质量的影响因素。结果:多元方差分析显示利培酮组明显高于传统药物组,差异具有统计学意义(P<0.01);多因素逐步回归分析显示,影响康复期患者生活质量的因素依次为病程、药物类型。结论:利培酮治疗组生活质量优于传统药物组;患者病程的长短,药物类型对生活质量有预测价值。

Objective：To explore the factors influencing the life quality of schizophrenic patients at recovery stage treated with Risperidone and conventional antipsychotics. Methods：The demographic data questionaire and WHOQOL-100 were used to evaluate the life quality of the patients with schizophrenia at their recovery stage and to analyze the influencing factors.Results： Muhielemen analysis of variance showed that there was significant difference between the two groups with regard to life quality. The life quality in the Risperidone treatment group was significantly higher than that in the conventional antipsychotics treatment group. Multiple factor gradual regressive analysis revealed that the factors influencing the life quality of the paitients with schizophrenia at their recovery stage were sequentially course of disease and drug category. Conclusions：The life quality of the patients in the Risperidone treatment group was better than that of the patients in the conventional antipsychotics treatment group,and the course of disease and drug category had prognostic value on life quality.