r-干扰素抑制人工晶体前膜和后发性白内障的临床研究

Clinical study of inhibition anterior membrane of intraocular lens and secondary cataract with r-interferon

目的观察r-干扰素(r-IFN)对白内障囊外摘除及人工晶体植入术后人工晶体前表面膜和后囊混浊的抑制作用。方法将老年性白内障病人90例随机分为两组:治疗组为r-干扰素组,即在行现代囊外摘除+人工晶体植入术时,用含r-干扰素4×103IU/mL的Ringer's液冲洗前房皮质;对照组为在行现代囊外摘除术+人工晶体植入术时,用不含r-干扰素的Ringer's液冲洗前房皮质。结果术后6个月时r-干扰素组病人的视力高于对照组(P<0.05),人工晶体前膜及后囊混浊情况明显比对照组减少(P<0.05)。结论r-干扰素可作为白内障人工晶体术后防治后发障的有效药物。

[Objective] To observe the inhibition from anterior membrane of intraocular lens and secondary cataract after extracapsular cataract extraction and implantation of the chamber lenses. [Methods] To divide 90 examples of patient of senile cataract into 2 groups at random： the therapeutical group is r-IFN group, namely eyes were irrigated with r-IFN solution （4×10^3 IU/mL） in the operation, another is the control groupwithout r-IFN. [Results] 6 months after the operation, the visual acuity in the drug group was markedly higher than that in the control group （P 〈0.05）, the anterior membrane of intraocular lens and the posterior capsular opacification were significantly less than those in the control group （P 〈0.05）. [Conclusion] r-IFN is the effective drug of inhibition anterior membrane of intraocular lens and secondary cataract.