禽流感病毒非结构蛋白NS1的分子生物学特性与功能

Molecular Biological Characteristics and Function for the Nonstructural Protein Protein NS1 of Avian influenza virus

禽流感严重威胁着世界养禽业及人类健康。随着对流感病毒研究的逐渐深入,人们己经从对流感病毒结构蛋白的研究转移到对非结构蛋白即NS1蛋白的研究上来。研究发现流感病毒的NS1蛋白与流感病毒所诱导的细胞凋亡之间存在一定的联系,其对凋亡的调节作用与流感病毒感染的细胞是否产生干扰素及其所感染的细胞系直接相关。NS1蛋白能够抑制病毒感染细胞干扰素的产生,在流感病毒颉颃干扰素的抗病毒效应中发挥了重要的作用。随着疫苗的广泛使用,无法区分野毒感染和疫苗免疫的禽群,干扰了禽流感的诊断,掩盖了禽流感的流行,增加了禽流感的预防难度。NS1蛋白作为流感病毒的非结构蛋白,具有高度的保守性,在临床应用中作为鉴别诊断免疫禽和自然感染禽的检测抗原具有广阔前景。

Avian influenza is seriously threatening the bird cultivation of the world and the human health. Along with gradual penetrating to avian influenza virus research, the people have changed the research aspect from structural protein to the nonstructural protein,which is the NS1 protein research. It has discovered that there is certain connection between the NS1 protein of avian influenza virus and apoptosis which is caused by the avian influenza virus. The NS1 protein＇s adjusting the effect to apoptosis is directly related to whether the cell infected by avian influenza virus produces interferon or not, and to the cells it infects. The NS1 protein can resistant the production of interferon produced by the viral infected cell, and has played a vital role. At present,many countries apply various vaccines to control and eliminate the bird flu. Along with the widespread applying of the vaccine, it is difficult to distinguish infection group from the vaccine immunized bird group. It has disturbed the diagnosis of avian influenza, concealed the popularity of the avian influenza, added to the difficulty of the avian influenza prevention. As the avian influenza virus nonstructural protein, the NS1 protein has the high conservative nature, and has the broad prospect in the clinical practice as the inspecting antigen in distinguishing and diagnosing between immunized birds and the naturally infected birds.