转化生长因子β1及其在肝癌形成中的作用

TGF-β1 and its role in hepatocarcinogenesis

转化生长因子β1（TGF-β1）是一种多功能细胞因子，在细胞生长、分化、细胞外基质形成、凋亡、细胞迁移等方面扮演重要角色。许多研究表明肝癌细胞中TGF-β1的mRNA和蛋白质的含量比正常组织的肝细胞显著升高。TGF-β1是肿瘤抑制因子，然而在许多肿瘤中却表现为促进肿瘤的形成，如促进细胞外基质沉积、抑制凋亡、降低患者免疫力。

Transforming growth factor-β1 （ TGF-β1 ） is a multifunction growth factor that plays a role in cell proliferation, differentiation, extracellular matrix production, apoptosis and cell migration. It has also been demonstrated that the production of TGF-β1 is markedly increased at both the mRNA and protein level in HCC cell in comparison to that in the cells of normal tissues. It is known that TGF-β1 is a tumor suppression cytokine, however, it promotes progression of tumorigenesis by accelerating extracellular matrix deposition, suppressing apoptosis,lowering immunity of patients in many tumors