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他汀类药物的作用多向性效应及其临床应用 被引量:4

Pleiotropic Effects and Clinical Application of Statins
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摘要 他汀类药物能显著降低总胆固醇、低密度脂蛋白胆固醇和升高高密度脂蛋白胆固醇,在急性冠状动脉综合征的治疗中发挥着稳定粥样硬化斑块、降低急性冠状动脉综合征患者急性期病死率的作用。近年来的临床和实验研究证实,他汀类具有作用多向性效应,可以防治20余种疾病,其中多数与调脂作用无关。 Statins can significantly reduce total cholesterol,low-density lipoprotein cholesterol,and can increase high-density lipoprotein cholesterol. It can stabilize atherosclerotic plaque in the treatment of acute coronary artery syndrome (ACS) ,and decrease the incidence of mortality in ACS. Statins have pleiotropic effects which have been proven in several clinical trials and experimental studies in recent years. They play important roles in the treatment and prevention of more than twenty kinds of disease, and most of the effects independent of lowering levels of lipid.
出处 《心血管病学进展》 CAS 2007年第3期448-452,共5页 Advances in Cardiovascular Diseases
关键词 他汀类 作用多向性效应 药物 statins pleiotropic effects drugs
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