维甲酸治疗急性早幼粒细胞白血病40例毒副反应的观察与护理

Observation and Nursing on the side effects of ATRA in Treatment of 40 Cases with Acute Promyelocytic Leukemia

目的:探讨维甲酸治疗急性早幼粒细胞白血病的毒副作用。方法:对本组40例急性早幼粒细胞白血病使用维甲酸过程出现毒副反应的观察与护理。结果:维甲酸治疗急性早幼粒细胞白血病疗效显著、毒副作用大。本组40例,35例完全缓解,3例死于脑出血,2例放弃治疗,无护理并发症。结论:早期采取有效护理措施,密切观察维甲酸应用过程中的情况,减少毒副作用,可提高患者的生命质量。

Objective：Study on the side effects of ATRA in Treatment of Acute Promylocytic Leukemia. Methods：Observation and nursing on the side effects of ATRA in treatment of 40 cases with acute promyelocytic leukemia. Results：Taking the effective measures of nursing on the patients and carefully observing the side effects of ATRA, we obtained better effect in nursing the patients with APL treated with ATRA. Conclusion：ATRA in treatment of APL can yield both remarkable rffect and severe side effects, but we can reduce the severe complication through careful nursing measures. Among of 40 cases ,35 cases obtained complete remission, 3 cases died of cerebral hemorrhage, and 2 cases gave up further treatment, none of them has nursing complications.