毛细支气管炎患儿血清IL-6、IL-8、INF-γ和TNF-α水平动态变化与病情关系的研究

Change of interleukin-6,interleukin-8,interferon gamma and TNF alpha in children with bronchiolitis

目的探讨毛细支气管炎患儿血清的IL-6、IL-8、INF-γ和TNF-α水平动态变化在呼吸道合胞病毒性毛细支气管炎发病中的作用。方法检测74例住院毛细支气管炎患儿急性期与恢复期血清的IL-6、IL-8、INF-γ和TNF-α水平,并与正常对照组进行比较。结果患儿组急性期血清IL-6、IL-8、和TNF-α水平显著高于恢复期和对照组(P<0·05),恢复期与健康对照组间无显著差异(P>0·05);患儿组急性期血清INF-γ水平显著底于恢复期和对照组(P<0·05),恢复期与健康对照组间无显著差异(P>0·05)。结论Th1/Th2失衡致IFN-γ水平降低在毛细支气管炎发病中起重要作用;IL-6与IL-8和TNF-α可以作为预测毛细支气管炎病情的实验室指标。

Objective To study the role of the interleukin-6, interleukin-8, TNF alpha and interferon gamma in infants with bronchiolitis induced by respiratory syncytial virus. Methods The serum levels of interleukin-6, interleukin-8, TNF alpha and interferon gamma were detected in 74 infants with bronchiolitis during acute stage and convalescence stage, and compared with those of normal control group. Results The serum levels of interleukin-6, interleukin-8 and TNF alpha during acute stage were significantly increased in comparison with those during convalescence stage （ P 〈 0. 05 ）, but no significant difference was found between those during convalescence stage and those of normal control group （ P 〉 0. 05 ）. The serum levels of interferon gamma during acute stage were significantly decreased compared with those during convalescence stage （P 〈 0. 05）, but no significant difference was found between those during convalescence stage and those in normal control group （ P 〉 0. 05 ）. Conclusion The decreased level of interferon gamma resulting from the ratio of Thl and Th2 disequilibrium plays an important role in development of bronchiolitis. The serum levels of interleukin-6, interleukin-8 and TNF alpha might be markers to predict the degree of bronchiolitis in infants.