单纯性甲状腺肿儿童血清微量元素失衡

Trace Element Imbalance in Children with Simple Goiter

为探讨微量元素在儿童甲状腺发育中的重要作用,了解单纯性甲状腺肿大与微量元素的关系。回顾性分析了34例单纯性甲状腺肿大儿童(A组)血清甲状腺相关激素及微量元素锌、铁、铜、钙、镁水平,同时测定了尿碘含量,与34名年龄匹配的儿童作对照(B组)。运用原子吸收分光光度法测定了血清微量元素含量,化学发光法测定了血清TT3、TT4、TSH水平,放射免疫法测定了甲状腺球蛋白抗体(TGA)、甲状腺微粒体抗体(TMA)。结果表明,A组患儿尿碘水平显著低于B组,并伴有血清铁、锌下降(P<0.05),分别为(18.87±5.26)μmol/mL、(15.9±5.03)μmol/mL,A组患儿甲状腺功能状态正常,但应注重补充微量元素,以满足甲状腺正常发育所需。

To evaluate the role of microelement on children with simple goiter in thyroid growth and development by detecting related thyroid hormone and microelement, and to reveal the relationship between simple goiter and trace element deficiency, a retrospective study was performed in 2005 for 34 children with simple goiter （A group） from Chongqing, a mountainous region of China. ioduria, serum TT3 ,TT4 ,TSH ,TGA,TMA and microelement were assayed in group A. Using atomic resorption spectrophotography to estimate microelement level and the level of TTs, TT4, TSH were estimated by chemiluminescence immunoassay, TGA, TMA were measured by radioimmunoassay. 34 age-matched children were considered as control group （group B）. The resules showed that ioduria in group A was lower than that in group B, accompanying with serum iron and zinc decreased （P〈0.05）, these were （18.87±5.26）μmol/mL, （15.9±5.03）μmol/mL respectively, but thyroid function was normal in group A. Therefore microelement iron and zinc were deficiency in children with simple goiter beside ioduria deficiency. To satisfy the need of thyroid growth and development, the children with simple goiter should pay more attention to complementing the trace element iron and zinc.